Анализ химического взаимодействия полигексанида с эндодонтическими ирригантами

ВВЕДЕНИЕ. Хронический апикальный периодонтит (ХАП) представляет сложность в эндодонтии из-за микробной резистентности и недостаточной эффективности протоколов дезинфекции. Полигексанид (PHMB) является перспективным ирригантом благодаря своим антимикробным свойствам. Однако взаимодействие PHMB с другими ирригантами требует дальнейшего изучения для разработки безопасных и эффективных протоколов.

ЦЕЛЬ. Оценить химическое взаимодействие PHMB с гипохлоритом натрия (NaOCl), перекисью водорода (H₂O₂), ЭДТА и хлоргексидином и выявить оптимальные протоколы ирригации.

МАТЕРИАЛЫ И МЕТОДЫ. Методом высокоэффективной жидкостной хроматографии (ВЭЖХ) изучались реакции PHMB с NaOCl, H₂O₂, ЭДТА и хлоргексидином через 30 минут, 1 час и 3 дня. Анализировались продукты реакции и химическая стабильность.

РЕЗУЛЬТАТЫ. PHMB образует осадок при смешивании с NaOCl, полностью исчезая из раствора. Реакция с H₂O₂ приводит к образованию новых соединений. ЭДТА не вызывает значительных негативных реакций. Смешивание с хлоргексидином сопровождается образованием новых продуктов и осадков. Последовательное применение ЭДТА и PHMB показало совместимость и эффективность.

ВЫВОДЫ. Полигексанид является перспективным ирригантом, особенно в сочетании с ЭДТА, обеспечивая удаление смазанного слоя и антисептическое действие без отрицательных взаимодействий. NaOCl и H₂O₂ требуют тщательной корректировки протоколов. Необходимы дополнительные исследования для подтверждения клинической эффективности и уточнения протоколов.

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