Treatment of chronic periodontitis using a preparation based on plant components in an experiment
G. A. Valeeva,
R. R. Haibullina,
K. V. Danilko,
O. R. Shangina,
L. P. Gerasimova,
M. R. Shamsiev,
M. I. Astakhova,
I. A. Galiahmetova https://doi.org/10.36377/1726-7242-2022-20-2-179-182
Abstract
Aim. Development of the chronic periodontitis treatment method using the medicamentation based on herbal components in the experiment.
Materials and methods. An experimental model of chronic periodontitis was created. Mesenchymal stem cells (MSC) from the extracted retained human tooth were obtained multipotent. The obtained MSCs were injected into the periodontalpockets together with the osteogenesis stimulator drug. Then a medicamentation based on plant components was applied.
Results. Periodontal pocket depth decreased to 1.5 ± 0.01 mm (P < 0.001). There was no tooth mobility. Three months after the therapeutic procedures radiographs of the rats showed signs of bone neoplasia. By 6 months these signs became more pronounced: the foci of stained osteoporosis disappeared and began to acquire a finely petrified structure, the contours of the interalveolar septa became clear and smooth with a simultaneous increase in the height of resorbed ridges of the interalveolar septa.
Conclusions. Experimental studies have shown pronounced therapeutic efficacy of the method for the treatment of destructive changes of the alveolar bone in periodontitis.
About the Authors
G. A. Valeeva
Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Postgraduate student of the Department of Therapeutic Dentistry
3, st. Lenina, Ufa, 450000
Competing Interests:
The authors declare no conflict of interests.
R. R. Haibullina
Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
MD, Professor of the Department of Therapeutic Dentistry
3, st. Lenina, Ufa, 450000
Competing Interests:
The authors declare no conflict of interests.
K. V. Danilko
Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Candidate of Biological Sciences, Senior Researcher at the Central Research Laboratory
3, st. Lenina, Ufa, 450000
Competing Interests:
The authors declare no conflict of interests.
O. R. Shangina
«All-Russian Center for Eye and Plastic Surgery»
Russian Federation
Competing Interests:
Russian Federation
MD, Professor of the Department of Human Anatomy named after prof. S. Z. Lukmanov. Deputy General Director of the Federal State Budgetary Institution
67k1 Rikhard Sorge st, Ufa, 450075
Competing Interests:
The authors declare no conflict of interests.
L. P. Gerasimova
Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
MD, Head of the Department of Therapeutic Dentistry
3, st. Lenina, Ufa, 450000
Competing Interests:
The authors declare no conflict of interests.
M. R. Shamsiev
Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Candidate of Medical Sciences, Associate Professor of the Department of Therapeutic Dentistry.
3, st. Lenina, Ufa, 450000
Competing Interests:
The authors declare no conflict of interests.
M. I. Astakhova
Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Candidate of Medical Sciences, Associate Professor of the Department of Therapeutic Dentistry
3, st. Lenina, Ufa, 450000
Competing Interests:
The authors declare no conflict of interests.
I. A. Galiahmetova
Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
CEO
3, st. Lenina, Ufa, 450000
Competing Interests:
The authors declare no conflict of interests.
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Review
For citations:
Valeeva G.A., Haibullina R.R., Danilko K.V., Shangina O.R., Gerasimova L.P., Shamsiev M.R., Astakhova M.I., Galiahmetova I.A. Treatment of chronic periodontitis using a preparation based on plant components in an experiment. Endodontics Today. 2022;20(2):179-182. (In Russ.) https://doi.org/10.36377/1726-7242-2022-20-2-179-182
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