Clinical application of collagen in combination with growth factors and cells in regenerative dentistry
https://doi.org/10.36377/ET-0146
Abstract
Type I collagen, being the main structural protein of the extracellular matrix, provides optimal conditions for cell adhesion and proliferation and can also serve as a system for localized delivery of bioactive molecules. However, for a number of clinical conditions, the regenerative capacity of collagen alone remains insufficient, which has stimulated the development of combined systems designed to enhance its regenerative potential. The combination of collagen implants with growth factors and stem cells represents a promising approach in regenerative dentistry. This review summarizes clinical studies focused on the use of collagen matrices combined with mesenchymal stem cells, dental pulp cells, fibroblasts, as well as with growth factors such as PDGF-BB, BMP-2, and FGF-2.
Despite the limited clinical evidence, the integration of collagen with bioactive components already demonstrates consistent advantages over conventional treatment methods. Studies show that these combined constructs accelerate the regeneration of hard and soft tissues, thereby reducing the need for autografts and minimizing surgical trauma.
Supporting agencies: The study was conducted within the framework of the state assignment of the Ministry of Health of the Russian Federation, project No. NZAF-2024-0025.
About the Authors
S. Yu. Voloshin
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Sergei Yu. Voloshin – Laboratory Assistant, Center for Innovative Collagen Developments, Institute of Regenerative Medicine, Biomedical Science and Technology Park
8c2 Trubetskaya Str., Moscow 119048, Russian Federation
Competing Interests:
The authors report no conflict of interest.
K. A. Gadzhieva
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Khadizhat A. Gadzhieva – Postgraduate Student, Department of Oral and Maxillofacial Surgery E.V. Borovsky Institute of Dentistry
8c2 Trubetskaya Str., Moscow 119048, Russian Federation
Competing Interests:
The authors report no conflict of interest.
K. R. Zhalilova
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Kamila R. Zhalilova – Student, N.V. Sklifosovsky Institute of Clinical Medicine
8c2 Trubetskaya Str., Moscow 119048, Russian Federation
Competing Interests:
The authors report no conflict of interest.
I. P. Ashurko
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Igor P. Ashurko – Dr. Sci. (Med.), Professor, Department of Oral and Maxillofacial Surgery E.V. Borovsky Institute of Dentistry
8c2 Trubetskaya Str., Moscow 119048, Russian Federation
Competing Interests:
The authors report no conflict of interest.
P. S. Timashev
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Petr S. Timashev – Dr. Sci. (Chem.), Professor, Scientific Director of the Biomedical Science and Technology Park
8c2 Trubetskaya Str., Moscow 119048, Russian Federation
Competing Interests:
The authors report no conflict of interest.
A. A. Antoshin
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Artem A. Antoshin – Cand. Sci. (Biol.), Head of the Center for Innovative Collagen Developments, Institute of Regenerative Medicine, Biomedical Science and Technology Park
8c2 Trubetskaya Str., Moscow 119048, Russian Federation
Competing Interests:
The authors report no conflict of interest.
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Review
For citations:
Voloshin S.Yu., Gadzhieva K.A., Zhalilova K.R., Ashurko I.P., Timashev P.S., Antoshin A.A. Clinical application of collagen in combination with growth factors and cells in regenerative dentistry. Endodontics Today. 2025;23(4):710-716. https://doi.org/10.36377/ET-0146
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