Immediate implant grafted with xenograft and hyaluronate verses xenograft and injectable platelet rich fibrin comparative study clinically and radiografically
https://doi.org/10.36377/ET-0162
Abstract
INTRODUCTION. Immediate implant placement offers clinical advantages include shortened treatment duration and alveolar bone preservation.To improve soft tissue healing and osseointegration, adjunctive grafting materials are frequently utilized. AIM of this study was to compare the efficacy of gap filling materials (xenograft and hyaluronate versus xenograft and I-PRF) of immediate implant in maxillary anterior and premolar region.
MATERIALS AND METHODS. A total of 20 patient enrolled in this study. Dental implant placed following a traumatic tooth extraction .the patients divided equally in two group: group A (n = 10) received xenograft and hyaluronate. while group B (n = 10) received xenograft and I-PRF. Clinically, Implant stability was assessed immediately and after 6 months postoperatively using penguin ® RFA device. Radiographically, the assessment of marginal bone loss and buccal bone thickness ,immediately and six months after implant placement using CBCT.
RESULTS. All dental implant in both group were successfully ossteointergrated and functionally stable. Regarding implant stability, plalatal bone loss and buccal bone thickness not significant difference between the two group while buccal bone loss statically significant between them.
CONCLUSIONS. Both grafting materials effectively preserved the ridge dimensions and supported implant stability, but xenograft combined with HA showed a modest advantage in maintaining the buccal bone crest.
About the Authors
B. S. Khairy
University of Anbar
Iraq
Competing Interests:
Iraq
Bdoor Salman Khairy Alhadithy – Master Student of Oral Surgery at University of Anbar, College of Dentistry
Anbar, Iraq
Competing Interests:
The authors report no conflict of interest.
A. J. Al-Naqeeb
University of Anbar
Iraq
Competing Interests:
Iraq
Ahmed Jassam Mohammed Al-Naqeeb – Lecturer at University of Anbar, College of Dentistry, Department of Oral and Maxillofacial Surgery
Anbar, Iraq
Competing Interests:
The authors report no conflict of interest.
References
1. Becker W., Clokie C., Sennerby L., Urist M.R., Becker B.E. Histologic findings after implantation and evaluation of different grafting materials and titanium micro screws into extraction sockets: case reports. J Periodontol. 1998;69(4):414–421. https://doi.org/10.1902/jop.1998.69.4.414
2. Froum S.J., Weinberg M.A., Tarnow D. Comparison of bioactive glass synthetic bone graft particles and open debridement in the treatment of human periodontal defects. A clinical study. J Periodontol. 1998;69(6):698–709. https://doi.org/10.1902/jop.1998.69.6.698
3. Botticelli D., Renzi A., Lindhe J., Berglundh T. Implants in fresh extraction sockets: a prospective 5-year follow-up clinical study. Clin Oral Implants Res. 2008;19(12):1226–1232. https://doi.org/10.1111/j.1600-0501.2008.01620.x
4. Liñares A., Dopico J., Magrin G., Blanco J. Critical review on bone grafting during immediate implant placement. Periodontol 2000. 2023;93(1):309–326. https://doi.org/10.1111/prd.12516
5. Javed F., Ahmed H.B., Crespi R., Romanos G.E. Role of primary stability for successful osseointegration of dental implants: Factors of influence and evaluation. Interv Med Appl Sci. 2013;5(4):162–67. https://doi.org/10.1556/IMAS.5.2013.4.3
6. Daniel D., Shetty V., Jose J., Kumar A.H., Santosh B.S., Saikrrupa S.P. The efficacy of synthetic allograft and bioresorbable xenograft in immediate implant procedures: A comparative clinical study. Journal of Dental Implants. 2020;10(2):93–98. https://doi.org/10.4103/jdi.jdi_12_20
7. He L., Lin Y., Hu X., Zhang Y., Wu H. A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(5):707–713. https://doi.org/10.1016/j.tripleo.2009.06.044
8. Dohan D.M., Choukroun J., Diss A., Dohan S.L., Dohan A.J., Mouhyi J., Gogly B. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e37–44. https://doi.org/10.1016/j.tripleo.2005.07.008
9. Passaretti F., Tia M., D’Esposito V., De Pascale M., Del Corso M., Sepulveres R. et al. Growth-promoting action and growth factor release by different platelet derivatives. Platelets. 2014;25(4):252–256. https://doi.org/10.3109/09537104.2013.809060
10. Zhao N., Wang X., Qin L., Zhai M., Yuan J. et al. Effect of hyaluronic acid in bone formation and its applications in dentistry. J Biomed Mater Res A. 2016;104(6):1560–1569. https://doi.org/10.1002/jbm.a.35681
11. Mendes R.M., Silva G.A., Lima M.F., Calliari M.V., Almeida A.P., Alves J.B., Ferreira A.J. Sodium hyaluronate accelerates the healing process in tooth sockets of rats. Arch Oral Biol. 2008;53(12):1155–1162. https://doi.org/10.1016/j.archoralbio.2008.07.001
12. Nevins M., Camelo M., De Paoli S., Friedland B., Schenk R.K., Parma-Benfenati S. et al. A study of the fate of the buccal wall of extraction sockets of teeth with prominent roots. Int J Periodontics Restorative Dent. 2006;26(1):19–29.
13. Baldini N., De Sanctis M., Ferrari M. Deproteinized bovine bone in periodontal and implant surgery. Dent Mater. 2011;27(1):61–70. https://doi.org/10.1016/j.dental.2010.10.017
14. Valentini P., Bosshardt D.D. 20-year follow-up in maxillary sinus floor elevation using bovine-derived bone mineral: a case report with histologic and histomorphometric evaluation. Int J Oral Maxillofac Implants. 2018;33(6):1345–1350. https://doi.org/10.11607/jomi.6884
15. Suárez-López Del Amo F., Monje A. Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review. J Periodontol. 2022;93(12):1827–1847. https://doi.org/10.1002/JPER.22-0069
16. Bornstein M.M., Hart C.N., Halbritter S.A., Morton D., Buser D. Early loading of nonsubmerged titanium implants with a chemically modified sand-blasted and acid-etched surface: 6-month results of a prospective case series study in the posterior mandible focusing on peri-implant crestal bone changes and implant stability quotient (ISQ) values. Clin Implant Dent Relat Res. 2009;11(4):338–347. https://doi.org/10.1111/j.1708-8208.2009.00148.x
17. Fu P.-S., Tseng F.-C., Lan T.-H., Lai P.-L., Chen C.-H., Chen J.-H. et al. Immediate implant placement with and without provisionalization: A comparison of a one-year longitudinal study. J Dent Sci. 2023;18(3):1361–1367. https://doi.org/10.1016/j.jds.2023.04.029
18. Hassanan A.M., El Naas S.S. Evaluation of a mixture of xenograft with injectable platelet rich fibrin (I-PRF) around immediate dental implants in infected sockets. Int J Chem Biochem Sci. 2023;12:78–86.
19. Misch C.E., Perel M.L., Wang H.-L., Sammartino G., Galindo-Moreno P., Trisi P. et al. Implant success, survival, and failure: the international congress of oral implantologists (ICOI) pisa consensus conference. Implant Dent. 2008;17(1):5–15. https://doi.org/10.1097/ID.0b013e3181676059
20. Abaza G., Abdel Gaber H.K., Afifi N.S., Adel-Khattab D. Injectable platelet rich fibrin versus hyaluronic acid with bovine derived xenograft for alveolar ridge preservation. A randomized controlled clinical trial with histomorphometric analysis. Clin Implant Dent Relat Res. 2024;26(1):88–102. https://doi.org/10.1111/cid.13289
21. Xing F., Zhou C., Hui D., Du C., Wu L., Wang L. et al. Hyaluronic acid as a bioactive component forbone tissue regeneration: Fabrication,modification, properties, and biological functions. Nanotechnol Rev. 2020;9:1059–1079. https://doi.org/10.1515/ntrev-2020-0084
22. Lin C.-Y., Kuo P.-J., Lin Y.-H., Lin C.-Y., Lin J.C-.Y., Chiu H.-C. et al. Fabrication of low-molecular-weight hyaluronic acid – carboxymethyl cellulose hybrid to promote bone growth in guided bone regeneration surgery: An animal study. Polymers. 2022;14(15):3211. https://doi.org/10.3390/polym14153211
23. Miron R.J., Fujioka-Kobayashi M., Hernandez M., Kandalam U., Zhang Y., Ghanaati S., Choukroun J. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. 2017;21(8):2619–2627. https://doi.org/10.1007/s00784-017-2063-9
Review
For citations:
Khairy B.S., Al-Naqeeb A.J. Immediate implant grafted with xenograft and hyaluronate verses xenograft and injectable platelet rich fibrin comparative study clinically and radiografically. Endodontics Today. 2026;24(1):78-85. https://doi.org/10.36377/ET-0162
Email this article 