Study of immunoglobulins in patients with herpes virus infection
https://doi.org/10.36377/ET-0201
Abstract
INTRODUCTION. Today, herpes virus infection is the leading cause of various clinical manifestations, high contagiousness, poor perinatal outcomes, and damage to all human systems and organs.
AIM. The purpose of this study is to examine the quantitative and qualitative composition of immunoglobulins in oral fluid and blood serum in patients with herpes virus infection.
MATERIALS AND METHODS. On the basis of the Department of Therapeutic Dentistry of the Privolzhsky Research Medical University (Nizhny Novgorod, Russian Federation), 25 patients suffering from herpes-virus infection of the oral cavity and the red border of the lips were examined. On the first day of the study and on the 14th day, the levels of secretory immunoglobulins, lysozyme, and the coefficient of local immunity factors were quantitatively determined.
RESULTS. When studying humoral immunity in the blood serum, there was a noticeably high level of IgG both on the 1st and 14th day of the study, which was also characteristic of IgM, and the concentration of IgA gradually increased by the end of the second week of the disease. The study of the content of immunoglobulin A in the oral fluid showed an increase in the titer by the end of the second week of the study, while the concentration of IgM was negligible, and the concentration of IgG slowly decreased by the 14th day.
CONCLUSIONS. When performing a correlation analysis between the groups of blood serum and oral fluid immunoglobulins, it was possible to trace similar changes in the ratio of data on their content, which allows us to use oral fluid indicators to assess the severity of herpes virus infection in the oral cavity and to monitor the treatment process.
About the Authors
O. A. Uspenskaya
Privolzhsky Research Medical University
Russian Federation
Competing Interests:
Russian Federation
Olga A. Uspenskaya – Dr. Sci. (Med.), Associate Professor, Head of the Department of Therapeutic Dentistry
10/1 Minin and Pozharsky Square, Nizhny Novgorod 603005, Russian Federation
Competing Interests:
The authors declare no conflict of interests.
S. A. Spiridonova
Privolzhsky Research Medical University
Russian Federation
Competing Interests:
Russian Federation
Sania A. Spiridonova – Cand. Sci. (Med.), Associate Professor, Department of Therapeutic Dentistry
10/1 Minin and Pozharsky Square, Nizhny Novgorod 603005, Russian Federation
Competing Interests:
The authors declare no conflict of interests.
E. D. Apokina
Privolzhsky Research Medical University
Russian Federation
Competing Interests:
Russian Federation
Ekaterina D. Apokina – Resident of the Department of Therapeutic Dentistry
10/1 Minin and Pozharsky Square, Nizhny Novgorod 603005, Russian Federation
Competing Interests:
The authors declare no conflict of interests.
E. N. Alyaseva
Privolzhsky Research Medical University
Russian Federation
Competing Interests:
Russian Federation
Ekaterina N. Alyaseva – Resident of the Department of Therapeutic Dentistry
10/1 Minin and Pozharsky Square, Nizhny Novgorod 603005, Russian Federation
Competing Interests:
The authors declare no conflict of interests.
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Review
For citations:
Uspenskaya O.A., Spiridonova S.A., Apokina E.D., Alyaseva E.N. Study of immunoglobulins in patients with herpes virus infection. Endodontics Today. 2026;24(2):375-381. https://doi.org/10.36377/ET-0201
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