Effect of dentin bio modifications and matrix metalloproteinase activity on bond strength – A systematic review and meta-analysis
https://doi.org/10.36377/ET-0071
Abstract
AIM. To evaluate effect of dentin bio-modifications and matrix metalloproteinase (MMP) inhibitors on dentin bonding.
METHODS. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and was registered in PROSPERO. A thorough search of Google scholar, Pubmed Central, EBSCO host was conducted from January 2000 to December 2023 to identify studies examining the impact of various dentin bio modifications and MMP inhibitors on dentin bonding. Quality assessment was performed using the Cochrane risk of bias (ROB) –2 tool for randomized controlled trials (RCTs), evaluating each study’s domains through Review Manager (RevMan) software version 5.3. The standardized mean difference (SMD) served as the summary statistic measure, employing a random-effect model with a significance threshold set at p < 0.05.
RESULTS. Sixteen studies met the eligibility criteria and underwent qualitative synthesis, with fifteen studies in meta-analysis. Upon quality assessment, the studies demonstrated a range of moderate to low risk of bias. A variety of dentin modifiers and MMP inhibitors were included, of which 2% chlorhexidine and benzalkonium chloride being the most studied in twelve and five studies respectively. The pooled estimate through SMD suggested that 2% CHX 2.28 (–3.69–0.03) and BAC 2.50 (–7.80–2.79) had an overall greater dentin bonding compared to other control measures used.
CONCLUSION. It was concluded that biomodifiers and MMP inhibitors have a positive effect on the bond strength of adhesives. It was seen that 2% CHX and BAC had greater dentin bond strength.
About the Authors
D. Agarwal
Dr D.Y. Patil Dental College & Hospital, Dr D.Y. Patil Vidyapeeth
India
Competing Interests:
India
Divyanshi Agarwal – Postgraduate Student, Department of Conservative Dentistry & Endodontics
Pimpri, Maharashtra
Competing Interests:
There are no funding and individual acknowledgments to declare.
S. R. Srinidhi
Dr D.Y. Patil Dental College & Hospital, Dr D.Y. Patil Vidyapeeth
India
Competing Interests:
India
Surya Raghavendra Srinidhi – Professor and Head of the Department, Department of Conservative Dentistry & Endodontics
Pimpri, Maharashtra
Competing Interests:
There are no funding and individual acknowledgments to declare.
S. D. Aggarwal
Dr D.Y. Patil Dental College & Hospital, Dr D.Y. Patil Vidyapeeth
India
Competing Interests:
India
Shalini D. Aggarwal – Professor, Department of Conservative Dentistry & Endodontics
Pimpri, Maharashtra
Competing Interests:
There are no funding and individual acknowledgments to declare.
P. Ingle
Dr D.Y. Patil Dental College & Hospital, Dr D.Y. Patil Vidyapeeth
India
Competing Interests:
India
Pushpal Ingle – Postgraduate Student, Department of Conservative Dentistry & Endodontics
Pimpri, Maharashtra
Competing Interests:
There are no funding and individual acknowledgments to declare.
S. Tandon
Dr D.Y. Patil Dental College & Hospital, Dr D.Y. Patil Vidyapeeth
India
Competing Interests:
India
Sayujya Tandon – Postgraduate Student
Pimpri, Maharashtra
Competing Interests:
There are no funding and individual acknowledgments to declare.
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Review
For citations:
Agarwal D., Srinidhi S.R., Aggarwal S.D., Ingle P., Tandon S. Effect of dentin bio modifications and matrix metalloproteinase activity on bond strength – A systematic review and meta-analysis. Endodontics Today. 2025;23(1):71-79. https://doi.org/10.36377/ET-0071
