This study aimed to evaluate the comparability of three approaches to 3D cephalometric analysis: manual tracing in Invivo (Human Invivo), automated tracing using Diagnocat AI, and AI-assisted cephalometry in Invivo (AI Invivo). Materials and methods. A total of 30 CBCT scans were analyzed retrospectively, and measurements included overjet, overbite, incisor inclination, and interincisal angles. Statistical analysis comprised descriptive statistics, normality testing, ANOVA or Kruskal–Wallis tests with post-hoc comparisons, and intraclass correlation coefficient (ICC) evaluation. Pairwise differences were interpreted relative to pooled standard deviation (SD): <1 SD indicated comparability, 1–2 SD a moderate deviation, and ≥2 SD a large deviation.Results demonstrated that for the majority of parameters, differences across all three methods were below one SD, confirming high comparability and reproducibility. No parameters exceeded the 2 SD threshold. Diagnocat AI provided clinically acceptable outcomes while offering practical advantages such as reduced operator variability, faster processing time, and lower cost compared to manual tracing and AI Invivo. Conclusion. These findings suggest that both Diagnocat AI and AI Invivo may serve as reliable alternatives or adjuncts to manual cephalometry in orthodontic practice.

INTRODUCTION. Dental pulp stem cells (DPSCs) are of interest in regenerative endodontics due to their multipotency. Mineral trioxide aggregate (MTA) is highly sought after due to its biocompatibility, but the limitations of long setting time and poor handling have created interest in newer products such as Baghdadite. To evaluate the biocompatibility and osteogenic potential of Baghdadite, MTA, and their combination on DPSCs using MTT and Alizarin Red assay.

MATERIALS AND METHODS. DPSCs were cultured and characterized by flow cytometry and CFU assays. Experimental groups (MTA, Baghdadite, MTA+Baghdadite) were exposed to cytotoxicity test (MTT assay) and mineralization test (Alizarin Red staining).

RESULTS. Cell viability of all the groups was higher than control. Combination group showed maximum viability (mean OD: 0.4066) than Baghdadite (0.3975) and MTA (0.3563). Alizarin Red staining showed the maximum mineralization in combination group (mean OD: 1.7069) than MTA (0.5788) and Baghdadite (0.4020).

CONCLUSIONS. The association of MTA and Baghdadite showed improved biocompatibility and osteogenic ability, which is promising for application as a pulp-capping agent in regenerative endodontics.

INTRODUCTION. Today, pronounced atrophic changes in the alveolar jaws processes are often diagnosed, requiring bone tissue expansion using autogenic bone tissues of the patient, where various medical instruments and methods are used. Meanwhile, the problems of their improvement, minimizing the trauma of interventions, increasing regenerative processes and clinical effectiveness, have not been fully resolved. Thus, our research related to the optimization of medical instruments and methods remains relevant.

AIM is optimization of bone augmentation in patients using the developed method of bone tissue sampling using an angular surgical tip with a protector-retractor with severe atrophy of the alveolar processes in preparation for dental implantation.

MATERIALS AND METHODS. We used the developed device and method for creating cortical bone cuts during bone autograft sampling in bone plastic using an angular surgical tip with a retractor protector (patent No. 233201 dated 11.04.2025, published by 11.04.2025 Buhl. No. 11; Patent Application 2025120686, W25048732, issued 27.07.2025). The research was carried out at the surgical department of the dental clinic of North-Eastern Federal University and dental clinic “Avandent” (Yakutsk). Inclusion criteria in the research were associated with the presence of partial secondary adentia with marked alveolar atrophy. Exclusion criteria: generalized pathologies of decompensated form, malignant neoplasms, diseases of the hematopoietic system and intolerance to local anesthetics. Each patient gave his written consent for interventions. There were 2 groups: the main group – 105 patients, aged 42–68 years old; control group – 33, aged 40-69 years old using a protective device made of D.M. Mukhamadiev’s plastic (patent RU 213 284 U1, A61S 1/16 of 05.09.2022). Statistical processing of the material was carried out according to standard methods.

RESULTS. The results characterized low-trauma, safety and efficiency of surgical interventions, and design features of developed protector-retractor with metal body and shortened irrigation tube for angular surgical tip provide tight fixation, as well as minimal delamination of mucoperiosteal flap, reusability of practical application and convenience of pre-sterilization cleaning. Whereas, the plastic tread does not have these advantages due to the design features and material of manufacture.

CONCLUSIONS. The developed method provides certain advantages associated with the presence of a thin metal protector-retractor body for the angular surgical tip, which provides the best view of the surgical field, increases the safety and effectiveness of surgical interventions.

INTRODUCTION. This article is devoted to the chronophysiological aspects of the prevention and treatment of dental diseases in children. The influence of biorhythms on the development, course, and prevention of dental pathologies in the pediatric population is considered a promising direction in modern dentistry. In both domestic and international literature, this issue is insufficiently addressed, which underscores the relevance of further research in this area.

AIM. To deepen understanding of chronodiagnosis and chronotherapy of dental diseases in children, aiming to optimize the treatment process through early diagnosis and the timely implementation of personalized preventive and therapeutic interventions.

MATERIALS AND METHODS. Within the framework of this article, an analytical review of domestic and international publications addressing biorhythmological and chronophysiological aspects of dental diseases was conducted. The analysis included an evaluation of data on the influence of circadian rhythms on the condition of dental hard tissues, periodontium, and oral mucosa, as well as the particularities of their consideration in the implementation of preventive and therapeutic interventions in children.

RESULTS. The conducted analysis demonstrated that the influence of biorhythms on the dental health of children is systemic in nature. Taking chronophysiological patterns into account enables increased effectiveness of preventive measures, improved treatment outcomes, and a reduction in the incidence of complications.

CONCLUSIONS. The chronophysiological approach in pediatric dentistry represents a promising direction capable of significantly enhancing the quality of dental care. Deepening knowledge of biorhythms and their application in practice will contribute to the development of personalized dentistry and stimulate professional interest in further investigation of the biorhythmological foundations of diagnosis and therapy.

INTRODUCTION. The study presents the results of a comparative evaluation of the effectiveness of mechanical and virtual articulators in the functional diagnosis of patients with temporomandibular joint (TMJ) disorders.

AIM. To assess the advantages and limitations of using mechanical and virtual articulators for analyzing dynamic occlusion in patients with internal TMJ pathology.

MATERIALS AND METHODS. A total of 52 patients (45 women and 7 men), aged 25 to 42 years, with occlusal disturbances caused by internal TMJ disorders, were examined. All patients underwent cone-beam computed tomography (CBCT) for TMJ assessment and axiographic recording (optical axiograph Dentograf Prosystom). The patients were divided into two groups: Group 1 (n = 26) was analyzed using a mechanical articulator, and Group 2 (n = 26) using a virtual articulator. CBCT and axiography data, as well as the results of dynamic occlusion evaluation (tooth contact in closure and opening, protrusion, and laterotrusion), were analyzed in both articulator types.

RESULTS. Mechanical articulators enabled the evaluation of dynamic occlusion with an effectiveness of 73.1%. Limitations were associated with their inability to accurately account for individual anatomical characteristics of the TMJs. Virtual articulators demonstrated higher effectiveness (92.3%) due to the integration of CBCT and axiography data, allowing detailed modeling of individual mandibular movements.

CONCLUSIONS. Virtual articulators show significant advantages over mechanical ones in assessing dynamic occlusion in patients with TMJ disorders, providing greater accuracy and personalization of the diagnostic process. Mechanical articulators demonstrated limited effectiveness and a considerable margin of error related to their non-individualized approach.

INTRODUCTION. The review aimed to evaluate the therapeutic efficacy of holy basil (ocimum sanctum) in managing oral submucous fibrosis (OSMF), focusing on its impact on clinical symptoms such as burning sensation, mouth opening, tongue protrusion, cheek flexibility, blanching, and fibrosis.

MATERIALS AND METHODS. A comprehensive search was conducted across PubMed-Medline, Scopus, Embase, Cochrane Library and Google Scholar from the earliest available date upto 5 th April, 2025. Studies included were randomized controlled trials (RCTs) and observational studies involving patients diagnosed with OSMF, assessing the efficacy of holy basil in any formulation (such as extract or oil) on clinical symptoms. Both Two reviewers independently performed data extraction and quality assessment using the Cochrane RoB 2.0 and ROBINS-I tools. Where appropriate, a metaanalysis (MA) was performed, where summarized raw mean (MRAW) standardized mean differences (SMDs) were calculated.

RESULTS. A total of 7 studies met the inclusion criteria, comprising 5 observational and 2 experimental studies conducted in India between 2017 and 2023. The MA demonstrated significant improvements in maximal mouth opening with MRAW = 36.14 mm; 95% confidence interval [CI]: 22.3–49.98) and reduction in burning sensation (SMD = 2.6; 95% CI: 1.94–3.25) in patients receiving holy basil-based treatments. Substantial heterogeneity was noted for mouth opening outcomes (I² = 96%), whereas the results for burning sensation were relatively consistent across studies (I² < 50%). Secondary outcomes, such as cheek flexibility, were reported in only one study, restricting broader generalization.

CONCLUSIONS. The findings suggest that Holy Basil, administered in various formulations, shows promising potential in improving key clinical symptoms such as maximal mouth opening, burning sensation, and tongue protrusion.

INTRODUCTION. The present study reports the outcomes of using occlusal splints in the comprehensive treatment of patients with internal temporomandibular joint (TMJ) disorders. The diagnosis of mandibular movement disorders was performed using an optical axiograph Dentograf Prosystom (Russia). The obtained axiographic data were utilized for the fabrication of myorelaxing and distraction splints. Axiography was repeated every three weeks to monitor treatment effectiveness. The position and function of the TMJ articular disc (AD) were evaluated by ultrasonography (US) one to two times per month.

AIM. To evaluate the effectiveness of various types of occlusal splints fabricated using mechanical and virtual articulators in the comprehensive treatment of patients with subluxation and chronic dislocation of the TMJ articular disc.

MATERIALS AND METHODS. Myorelaxing and distraction splints for patients with subluxation and chronic dislocation of the AD were fabricated using two approaches: (1) The classical method, involving a mechanical facebow and a mechanical articulator; (2) The CAD/CAM technology, employing a virtual articulator.

RESULTS. The effectiveness of myorelaxing splints fabricated with the mechanical articulator was 81.8%, while for those produced using the virtual articulator it reached 88.0%. The effectiveness of distraction splints fabricated with the mechanical articulator was 55.6%, whereas modeling with the virtual articulator yielded 68.8%. Based on the obtained data, an algorithm was developed for the clinical use of occlusal splints fabricated by different methods (using mechanical or virtual articulators) in patients with internal TMJ disorders.

CONCLUSIONS. Following the diagnosis confirmed by magnetic resonance imaging (MRI), axiography, and ultrasonography, patients were divided into two groups: (1) In Group I (patients with articular disc subluxation), myorelaxing splints were applied at the initial treatment stage and subsequently remodeled into separating (discluding) splints after disc repositioning to consolidate the therapeutic outcome; (2) In Group II (patients with chronic disc dislocation), distraction splints were used at the first stage with subsequent occlusal correction. After the normalization of mandibular movements and TMJ disc repositioning, the distraction splints were remodeled into separating splints to stabilize the new maxillomandibular relationship. The use of a virtual articulator demonstrated higher treatment effectiveness compared to the mechanical method, confirming its clinical relevance and potential integration into complex TMJ disorder management protocols.